Protein Synthesis by Human Platelets
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چکیده
منابع مشابه
Protein synthesis by human platelets.
The present studies show that human platelets can incorporate uniformly labeled W-L-leucine into trichloracetic acid-precipitable material. This material is digested by Pronase but not by deoxyribonuclease or ribonuclease. Acid hydrolysis of the material liberates a compound with chromatographic properties identical with those of authentic r,-leucine. The incorporation of uniformly labeled 14C-...
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Platelet homogenates contain an ethanolaminephosphotransferase (EC 2.7.8.1) that catalyzes the synthesis of ethanolamine phosphoglycerides from cytidine-5'-diphosphate ethanolamine and 1-radyl-2-acyl-sn-glycerols. The enzyme is particulate-bound and requires Mn2+ and bile salts for optimal activity. The apparent Km of the enzyme for cytidine-5'-diphosphate ethanolamine is 1.6 X 10(-5) M when th...
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Incubation of intact but not disrupted platelets with thrombin resulted in the release of thrombin-sensitive protein from the platelet membrane. The rapid release of this protein (Ti < 15 sec) at low concentrations of thrombin suggested that removal of thrombin-sensitive protein from the platelet membrane is an integral part of the platelet release reaction. This hypothesis is supported by the ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1967
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)96021-7